Novel pathways of transcriptional and post-transcriptional regulation of post-integrative HIV-1 latency
نویسندگان
چکیده
منابع مشابه
Novel pathways of transcriptional and post-transcriptional regulation of post-integrative HIV-1 latency
Methods We identified several levels of transcriptional and posttranscriptional control of viral genes expression. By looking at the organization of chromatin at the site of integration by chromatin conformation capture and in situ hybridization, we found that chromatin imposes silencing in a highly specific spatial and temporal pattern. We also identified several cellular factors that interact...
متن کاملDynamic Post-Transcriptional Regulation of HIV-1 Gene Expression
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev. Tat promotes the elongation of RNA polymerase while Rev mediates the nuclear export of viral RNAs that contain the Rev-responsive RNA element (RRE). These RNAs are exported fro...
متن کاملTranscription and post-transcriptional regulation of spermatogenesis.
Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards understanding such regulatory mechanisms a...
متن کاملTranscriptional and post-translational regulation of adiponectin.
Adiponectin is an adipose-tissue-derived hormone with anti-diabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with o...
متن کاملPost-transcriptional and post-translational regulation of Bcl2.
Bcl2 is an important pro-survival protein that has an essential function in normal immunity and whose constitutive expression leads to the development of lymphomas. Although transcriptional control of Bcl2 has been reported, increasing evidence suggests an important component of Bcl2 regulation is post-transcriptional. Phosphorylation of Bcl2 has been shown to enhance activity to allow response...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the International AIDS Society
سال: 2010
ISSN: 1758-2652
DOI: 10.1186/1758-2652-13-s3-o4